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MASTL

CANCER ATLAS

Gene description

 Microtubule associated serine/threonine kinase-like

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027175

GENE INFORMATION

Gene name

 MASTL (HGNC Symbol)

Synonyms

 FLJ14813, Gwl, THC2

Description

 Microtubule associated serine/threonine kinase-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 27154824 - 27186924

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120539 (version 83.38)

Entrez gene

 84930

UniProt

 Q96GX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GX5

Antibodypedia

 MASTL antibodies

PROTEIN BROWSER
MASTL-001
MASTL-002
MASTL-003
MASTL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MASTL-001
ENSP00000343446
ENST00000342386
Q96GX5 [Direct mapping]
Serine/threonine-protein kinase greatwall
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032154 [cleavage furrow]
GO:0034048 [negative regulation of protein phosphatase type 2A activity]
GO:0035556 [intracellular signal transduction]
GO:0040020 [regulation of meiotic nuclear division]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
Show all
 840 aa
92.9 kDa 		No 0
MASTL-002
ENSP00000478938
ENST00000477034
A0A087WUU7 [Direct mapping]
Serine/threonine-protein kinase greatwall
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 479 aa
53.3 kDa 		No 0
MASTL-003
ENSP00000365113
ENST00000375946
Q96GX5 [Direct mapping]
Serine/threonine-protein kinase greatwall
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032154 [cleavage furrow]
GO:0034048 [negative regulation of protein phosphatase type 2A activity]
GO:0035556 [intracellular signal transduction]
GO:0040020 [regulation of meiotic nuclear division]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
Show all
 878 aa
97.2 kDa 		No 0
MASTL-004
ENSP00000365107
ENST00000375940
Q96GX5 [Direct mapping]
Serine/threonine-protein kinase greatwall
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007147 [female meiosis II]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032154 [cleavage furrow]
GO:0034048 [negative regulation of protein phosphatase type 2A activity]
GO:0035556 [intracellular signal transduction]
GO:0040020 [regulation of meiotic nuclear division]
GO:0051301 [cell division]
GO:0051487 [activation of anaphase-promoting complex activity involved in meiotic cell cycle]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
Show all
 879 aa
97.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.