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EPC1

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GENERAL INFORMATION

Gene name

 EPC1

Gene description

 Enhancer of polycomb homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 EPC1 (HGNC Symbol)

Synonyms

 Epl1

Description

 Enhancer of polycomb homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 10

Cytoband

 p11.22

Chromosome location (bp)

 32267751 - 32378798

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120616 (version 83.38)

Entrez gene

 80314

UniProt

 Q9H2F5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2F5

Antibodypedia

 EPC1 antibodies

PROTEIN BROWSER
EPC1-001
EPC1-002
EPC1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPC1-001
ENSP00000364251
ENST00000375110
Q9H2F5 [Direct mapping]
Enhancer of polycomb homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0031965 [nuclear membrane]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 763 aa
85.2 kDa 		No 0
EPC1-002
ENSP00000318559
ENST00000319778
Q9H2F5 [Direct mapping]
Enhancer of polycomb homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0031965 [nuclear membrane]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 813 aa
90.9 kDa 		No 0
EPC1-004
ENSP00000263062
ENST00000263062
Q9H2F5 [Direct mapping]
Enhancer of polycomb homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0031965 [nuclear membrane]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0035886 [vascular smooth muscle cell differentiation]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 836 aa
93.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.