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ENOX1

GENERAL INFORMATION

Gene name

 ENOX1

Gene description

 Ecto-NOX disulfide-thiol exchanger 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA038355
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ENOX1 (HGNC Symbol)

Synonyms

 cCNOX, CNOX, FLJ10094, PIG38

Description

 Ecto-NOX disulfide-thiol exchanger 1 (HGNC Symbol)

Entrez gene summary

 Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al., 2005 [PubMed 15882838]).[supplied by OMIM, Mar 2008]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 43213518 - 43786908

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120658 (version 83.38)

Entrez gene

 55068

UniProt

 Q8TC92 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TC92

Antibodypedia

 ENOX1 antibodies

PROTEIN BROWSER
ENOX1-001
ENOX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENOX1-001
ENSP00000261488
ENST00000261488
Q8TC92 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 1 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
A0A024RDT8 [Target identity:100%; Query identity:100%]
Proliferation-inducing protein 38, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0048511 [rhythmic process]
GO:0055114 [oxidation-reduction process]
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 643 aa
73.3 kDa 		No 0
ENOX1-201
ENSP00000415054
ENST00000412891
Q8TC92 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 1 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
A0A024RDT8 [Target identity:100%; Query identity:100%]
Proliferation-inducing protein 38, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0048511 [rhythmic process]
GO:0055114 [oxidation-reduction process]
Show all
 643 aa
73.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.