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TNFSF11

GENERAL INFORMATION

Gene name

 TNFSF11

Gene description

 Tumor necrosis factor (ligand) superfamily, member 11

Protein class

 Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (small intestine, testis)
FANTOM5:Tissue enhanced (appendix, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA045142 , CAB009193
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lymph node)

GENE INFORMATION

Gene name

 TNFSF11 (HGNC Symbol)

Synonyms

 CD254, ODF, OPGL, RANKL, TRANCE

Description

 Tumor necrosis factor (ligand) superfamily, member 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 42562736 - 42608013

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120659 (version 83.38)

Entrez gene

 8600

UniProt

 O14788 (UniProt - Evidence at protein level)

neXtProt

 NX_O14788

Antibodypedia

 TNFSF11 antibodies

PROTEIN BROWSER
TNFSF11-001
TNFSF11-002
TNFSF11-201
TNFSF11-202
TNFSF11-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFSF11-001
ENSP00000381775
ENST00000398795
O14788 [Direct mapping]
Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
Q5T9Y4 [Target identity:100%; Query identity:100%]
Tumor necrosis factor (Ligand) superfamily, member 11; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_c
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0001503 [ossification]
GO:0002158 [osteoclast proliferation]
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007257 [activation of JUN kinase activity]
GO:0009887 [organ morphogenesis]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030316 [osteoclast differentiation]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0038001 [paracrine signaling]
GO:0042327 [positive regulation of phosphorylation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045453 [bone resorption]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050870 [positive regulation of T cell activation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055074 [calcium ion homeostasis]
GO:0060749 [mammary gland alveolus development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2001206 [positive regulation of osteoclast development]
Show all
 317 aa
35.5 kDa 		No 1
TNFSF11-002
ENSP00000351347
ENST00000358545
O14788 [Direct mapping]
Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
Q54A98 [Target identity:100%; Query identity:100%]
Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
Show all
CD markers
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030316 [osteoclast differentiation]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050870 [positive regulation of T cell activation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:1902533 [positive regulation of intracellular signal transduction]
Show all
 244 aa
27.7 kDa 		No 0
TNFSF11-201
ENSP00000239849
ENST00000239849
O14788 [Direct mapping]
Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030316 [osteoclast differentiation]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050870 [positive regulation of T cell activation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:1902533 [positive regulation of intracellular signal transduction]
Show all
 270 aa
30.5 kDa 		Yes 0
TNFSF11-202
ENSP00000384042
ENST00000405262
O14788 [Direct mapping]
Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
Q54A98 [Target identity:100%; Query identity:100%]
Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
Show all
CD markers
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030316 [osteoclast differentiation]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050870 [positive regulation of T cell activation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:1902533 [positive regulation of intracellular signal transduction]
Show all
 244 aa
27.7 kDa 		No 0
TNFSF11-203
ENSP00000444913
ENST00000544862
O14788 [Direct mapping]
Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
Q54A98 [Target identity:100%; Query identity:100%]
Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
Show all
CD markers
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030316 [osteoclast differentiation]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050870 [positive regulation of T cell activation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion]
GO:0071847 [TNFSF11-mediated signaling pathway]
GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling]
GO:1902533 [positive regulation of intracellular signal transduction]
Show all
 244 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.