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Tumor necrosis factor (ligand) superfamily, member 11
Protein class
Cancer-related genes CD markers Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Tumor necrosis factor (ligand) superfamily, member 11 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
O14788 [Direct mapping] Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form Q54A98 [Target identity:100%; Query identity:100%] Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
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CD markers Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs
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GO:0002548 [monocyte chemotaxis] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030316 [osteoclast differentiation] GO:0032813 [tumor necrosis factor receptor superfamily binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034112 [positive regulation of homotypic cell-cell adhesion] GO:0043406 [positive regulation of MAP kinase activity] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045780 [positive regulation of bone resorption] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050870 [positive regulation of T cell activation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051466 [positive regulation of corticotropin-releasing hormone secretion] GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion] GO:0071847 [TNFSF11-mediated signaling pathway] GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling] GO:1902533 [positive regulation of intracellular signal transduction]
O14788 [Direct mapping] Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form Q54A98 [Target identity:100%; Query identity:100%] Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
Show all
CD markers Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030316 [osteoclast differentiation] GO:0032813 [tumor necrosis factor receptor superfamily binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034112 [positive regulation of homotypic cell-cell adhesion] GO:0043406 [positive regulation of MAP kinase activity] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045780 [positive regulation of bone resorption] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050870 [positive regulation of T cell activation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051466 [positive regulation of corticotropin-releasing hormone secretion] GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion] GO:0071847 [TNFSF11-mediated signaling pathway] GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling] GO:1902533 [positive regulation of intracellular signal transduction]
O14788 [Direct mapping] Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form Q54A98 [Target identity:100%; Query identity:100%] Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
Show all
CD markers Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs
Show all
GO:0002548 [monocyte chemotaxis] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030316 [osteoclast differentiation] GO:0032813 [tumor necrosis factor receptor superfamily binding] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034112 [positive regulation of homotypic cell-cell adhesion] GO:0043406 [positive regulation of MAP kinase activity] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045780 [positive regulation of bone resorption] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050870 [positive regulation of T cell activation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051466 [positive regulation of corticotropin-releasing hormone secretion] GO:0071812 [positive regulation of fever generation by positive regulation of prostaglandin secretion] GO:0071847 [TNFSF11-mediated signaling pathway] GO:0071848 [positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling] GO:1902533 [positive regulation of intracellular signal transduction]