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Strong cytoplasmic staining was observed in cases of hepatocellular carcinomas while moderate positivity was observed in cases of thyroid, prostate, colorectal, urothelial and pancreatic cancers. Remaining cancer cells were generally negative.
The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]