Cell atlas - WBP4 - The Human Protein Atlas

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WBP4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane
	Vesicles

Human cell
	Nucleoplasm
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	WBP4
Gene description	WW domain binding protein 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Vesicles (uncertain), Plasma membrane (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA038965 , HPA058738
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & vesicles.

Main location

Nucleoplasm (supported)

Additional location

Vesicles (uncertain), Plasma membrane (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038965	A-431	Nucleoplasm
HPA038965	A-431	Plasma membrane
HPA038965	U-2 OS	Nucleoplasm
HPA038965	U-251 MG	Nucleoplasm
HPA058738	BJ	Nucleoplasm
HPA058738	BJ	Vesicles
HPA058738	U-2 OS	Nucleoplasm
HPA058738	U-2 OS	Vesicles
HPA058738	U-251 MG	Nucleoplasm
HPA058738	U-251 MG	Vesicles

GENE INFORMATION
Gene name	WBP4 (HGNC Symbol)
Synonyms	FBP21, MGC117310
Description	WW domain binding protein 4 (HGNC Symbol)
Entrez gene summary	This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q14.11
Chromosome location (bp)	41061274 - 41084006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120688 (version 83.38)
Entrez gene	11193
UniProt	O75554 (UniProt - Evidence at protein level)
neXtProt	NX_O75554
Antibodypedia	WBP4 antibodies

PROTEIN BROWSER

WBP4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WBP4-001 ENSP00000368801 ENST00000379487	O75554 [Direct mapping] WW domain-binding protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0045292 [mRNA cis splicing, via spliceosome] GO:0070064 [proline-rich region binding] Show all	376 aa 42.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.