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Malignant cells showed weak to moderate cytoplasmic positivity with additional nucleolar staining in many cases. A few cases of malignant melanoma, ovarian, skin, testis, colorectal and liver cancers exhibited strong positivity. Malignant gliomas and thyroid cancers were weakly stained or negative.
Most of the cancer cells displayed weak to moderate cytoplasmic and nuclear positivity. Lymphomas along with several breast, prostate, cervical and endometrial cancers were negative.
Squamous cell carcinomas of head and neck cancers and papillary adenocarcinomas of thyroid showed strong membranous and cytoplasmic staining. Several cases of skin, urothelial and renal cancers displayed moderate to strong positivity. Several cases of gliomas, lymphomas, melanomas, liver and pancreatic cancers displayed moderate to strong cytoplasmic positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KBTBD7 (HGNC Symbol)
Synonyms
DKFZP434E2318
Description
Kelch repeat and BTB (POZ) domain containing 7 (HGNC Symbol)