Expression of ALG5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

ALG5, dolichyl-phosphate beta-glucosyltransferase

Protein class

Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA007989

GENE INFORMATION
Gene name	ALG5 (HGNC Symbol)
Synonyms	bA421P11.2
Description	ALG5, dolichyl-phosphate beta-glucosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	36949775 - 37000261
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120697 (version 83.38)
Entrez gene	29880
UniProt	Q9Y673 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y673
Antibodypedia	ALG5 antibodies

PROTEIN BROWSER

ALG5-001	ALG5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG5-001 ENSP00000239891 ENST00000239891	Q9Y673 [Direct mapping] Dolichyl-phosphate beta-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0004576 [oligosaccharyl transferase activity] GO:0004581 [dolichyl-phosphate beta-glucosyltransferase activity] GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006506 [GPI anchor biosynthetic process] GO:0007368 [determination of left/right symmetry] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019348 [dolichol metabolic process] GO:0035269 [protein O-linked mannosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	324 aa 36.9 kDa	Yes	0
ALG5-201 ENSP00000390533 ENST00000443765	Q9Y673 [Direct mapping] Dolichyl-phosphate beta-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004169 [dolichyl-phosphate-mannose-protein mannosyltransferase activity] GO:0004576 [oligosaccharyl transferase activity] GO:0004581 [dolichyl-phosphate beta-glucosyltransferase activity] GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006506 [GPI anchor biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019348 [dolichol metabolic process] GO:0035269 [protein O-linked mannosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	294 aa 33.5 kDa	Yes	1