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ARL1

GENERAL INFORMATION

Gene name

 ARL1

Gene description

 ADP-ribosylation factor-like 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA073012
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARL1 (HGNC Symbol)

Synonyms

 ARFL1

Description

 ADP-ribosylation factor-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 q23.2

Chromosome location (bp)

 101393120 - 101407820

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120805 (version 83.38)

Entrez gene

 400

UniProt

 P40616 (UniProt - Evidence at protein level)

neXtProt

 NX_P40616

Antibodypedia

 ARL1 antibodies

PROTEIN BROWSER
ARL1-001
ARL1-004
ARL1-005
ARL1-007
ARL1-008
ARL1-010
ARL1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL1-001
ENSP00000261636
ENST00000261636
P40616 [Direct mapping]
ADP-ribosylation factor-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007030 [Golgi organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0009404 [toxin metabolic process]
GO:0015031 [protein transport]
GO:0019904 [protein domain specific binding]
GO:0031584 [activation of phospholipase D activity]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046872 [metal ion binding]
GO:0048193 [Golgi vesicle transport]
GO:0070062 [extracellular exosome]
Show all
 181 aa
20.4 kDa 		No 0
ARL1-004
ENSP00000439590
ENST00000539055
B4DZG7 [Direct mapping]
ADP-ribosylation factor-like protein 1; cDNA FLJ50309, highly similar to ADP-ribosylation factor-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 135 aa
15.4 kDa 		No 0
ARL1-005
ENSP00000441808
ENST00000536227
P40616 [Direct mapping]
ADP-ribosylation factor-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007030 [Golgi organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0009404 [toxin metabolic process]
GO:0015031 [protein transport]
GO:0019904 [protein domain specific binding]
GO:0031584 [activation of phospholipase D activity]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 164 aa
18.6 kDa 		No 0
ARL1-007
ENSP00000448912
ENST00000551671
F8VYN9 [Direct mapping]
ADP-ribosylation factor-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
Show all
 194 aa
21.8 kDa 		No 0
ARL1-008
ENSP00000447405
ENST00000551688
F8W1Z8 [Direct mapping]
ADP-ribosylation factor-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
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 52 aa
5.8 kDa 		No 0
ARL1-010
ENSP00000450315
ENST00000548070
F8VP99 [Direct mapping]
ADP-ribosylation factor-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 17 aa
1.8 kDa 		No 0
ARL1-011
ENSP00000448850
ENST00000551828
P40616 [Direct mapping]
ADP-ribosylation factor-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007030 [Golgi organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0009404 [toxin metabolic process]
GO:0015031 [protein transport]
GO:0019904 [protein domain specific binding]
GO:0031584 [activation of phospholipase D activity]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 164 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.