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Most cancers displayed weak to moderate cytoplasmic immunoreactivity. A few cases of liver, pancreatic, stomach, endometrial and cervical cancers exhibited strong positivity. A majority of urothelial cancers, malignant lymphomas and gliomas were negative.
GENE INFORMATION
Gene name
TNFRSF10B (HGNC Symbol)
Synonyms
CD262, DR5, KILLER, TRAIL-R2, TRICK2A, TRICKB
Description
Tumor necrosis factor receptor superfamily, member 10b (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]