Tissue expression of SORBS3 - Summary - The Human Protein Atlas

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SORBS3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SORBS3
Gene description	Sorbin and SH3 domain containing 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA015849
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SORBS3 (HGNC Symbol)
Synonyms	SCAM-1, SH3D4, vinexin
Description	Sorbin and SH3 domain containing 3 (HGNC Symbol)
Entrez gene summary	This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22544986 - 22575788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120896 (version 83.38)
Entrez gene	10174
UniProt	O60504 (UniProt - Evidence at protein level)
neXtProt	NX_O60504
Antibodypedia	SORBS3 antibodies

PROTEIN BROWSER

SORBS3-001	SORBS3-014	SORBS3-019	SORBS3-021	SORBS3-030	SORBS3-031	SORBS3-032

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SORBS3-001 ENSP00000240123 ENST00000240123	O60504 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0008134 [transcription factor binding] GO:0017166 [vinculin binding] GO:0031589 [cell-substrate adhesion] GO:0043410 [positive regulation of MAPK cascade] GO:0051495 [positive regulation of cytoskeleton organization] GO:0051496 [positive regulation of stress fiber assembly] Show all	671 aa 75.3 kDa	No	0
SORBS3-014 ENSP00000431128 ENST00000523900	E5RJP2 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 19.7 kDa	No	0
SORBS3-019 ENSP00000429479 ENST00000522721	E5RIA0 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	94 aa 10.5 kDa	No	0
SORBS3-021 ENSP00000428678 ENST00000523348	H0YB51 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	227 aa 25.1 kDa	No	0
SORBS3-030 ENSP00000428102 ENST00000520563	H0YAU6 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 17.2 kDa	No	0
SORBS3-031 ENSP00000428327 ENST00000517962	H0YAZ3 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	186 aa 20.4 kDa	No	0
SORBS3-032 ENSP00000429764 ENST00000523965	O60504 [Direct mapping] Vinexin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0017166 [vinculin binding] GO:0051495 [positive regulation of cytoskeleton organization] GO:0051496 [positive regulation of stress fiber assembly] Show all	329 aa 36.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.