Cell atlas - PPP3CC - The Human Protein Atlas

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PPP3CC

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PPP3CC
Gene description	Protein phosphatase 3, catalytic subunit, gamma isozyme
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA023396
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023396	A-431	Vesicles
	HPA023396	U-2 OS	Vesicles
	HPA023396	U-251 MG	Vesicles

GENE INFORMATION
Gene name	PPP3CC (HGNC Symbol)
Synonyms	CALNA3, PP2Bgamma
Description	Protein phosphatase 3, catalytic subunit, gamma isozyme (HGNC Symbol)
Entrez gene summary	Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22440819 - 22541142
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120910 (version 83.38)
Entrez gene	5533
UniProt	P48454 (UniProt - Evidence at protein level)
neXtProt	NX_P48454
Antibodypedia	PPP3CC antibodies

PROTEIN BROWSER

PPP3CC-001	PPP3CC-002	PPP3CC-003	PPP3CC-004	PPP3CC-005	PPP3CC-006	PPP3CC-008	PPP3CC-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP3CC-001 ENSP00000289963 ENST00000289963	P48454 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0006915 [apoptotic process] GO:0012501 [programmed cell death] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] Show all	502 aa 57.1 kDa	No	0
PPP3CC-002 ENSP00000240139 ENST00000240139	P48454 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0006915 [apoptotic process] GO:0012501 [programmed cell death] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] Show all	512 aa 58.1 kDa	No	0
PPP3CC-003 ENSP00000380878 ENST00000397775	P48454 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0006915 [apoptotic process] GO:0007420 [brain development] GO:0012501 [programmed cell death] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] Show all	521 aa 59.3 kDa	No	0
PPP3CC-004 ENSP00000429379 ENST00000518852	G3V111 [Direct mapping] Serine/threonine-protein phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016787 [hydrolase activity] Show all	326 aa 37.5 kDa	No	0
PPP3CC-005 ENSP00000430783 ENST00000522034	H0YC26 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	209 aa 24.1 kDa	No	0
PPP3CC-006 ENSP00000428358 ENST00000522000	H0YB02 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	153 aa 17.2 kDa	No	0
PPP3CC-008 ENSP00000430555 ENST00000523620	E5RJH4 [Direct mapping] Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	134 aa 15.2 kDa	No	0
PPP3CC-009 ENSP00000428390 ENST00000521651	H0YB04 [Direct mapping] Serine/threonine-protein phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016787 [hydrolase activity] Show all	202 aa 23.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.