Fields »
ABOUT
HELP
BLOG
TNFRSF8

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TNFRSF8

Gene description

 Tumor necrosis factor receptor superfamily, member 8

Protein class

 Cancer-related genes
CD markers
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TNFRSF8 (HGNC Symbol)

Synonyms

 CD30, D1S166E, KI-1

Description

 Tumor necrosis factor receptor superfamily, member 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 12063377 - 12144207

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120949 (version 83.38)

Entrez gene

 943

UniProt

 P28908 (UniProt - Evidence at protein level)

neXtProt

 NX_P28908

Antibodypedia

 TNFRSF8 antibodies

PROTEIN BROWSER
TNFRSF8-001
TNFRSF8-002
TNFRSF8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF8-001
ENSP00000263932
ENST00000263932
P28908 [Direct mapping]
Tumor necrosis factor receptor superfamily member 8
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0045556 [positive regulation of TRAIL biosynthetic process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097190 [apoptotic signaling pathway]
Show all
 595 aa
63.7 kDa 		Yes 1
TNFRSF8-002
ENSP00000398337
ENST00000413146
P28908 [Direct mapping]
Tumor necrosis factor receptor superfamily member 8
Show all
CD markers
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0045556 [positive regulation of TRAIL biosynthetic process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097190 [apoptotic signaling pathway]
Show all
 132 aa
14.1 kDa 		No 0
TNFRSF8-201
ENSP00000390650
ENST00000417814
P28908 [Direct mapping]
Tumor necrosis factor receptor superfamily member 8
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0045556 [positive regulation of TRAIL biosynthetic process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097190 [apoptotic signaling pathway]
Show all
 483 aa
50.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.