Tissue expression of LYPLA1 - Summary - The Human Protein Atlas

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LYPLA1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LYPLA1
Gene description	Lysophospholipase I
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA050941
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LYPLA1 (HGNC Symbol)
Synonyms	LPL1
Description	Lysophospholipase I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q11.23
Chromosome location (bp)	54046367 - 54102017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120992 (version 83.38)
Entrez gene	10434
UniProt	O75608 (UniProt - Evidence at protein level)
neXtProt	NX_O75608
Antibodypedia	LYPLA1 antibodies

PROTEIN BROWSER

LYPLA1-001	LYPLA1-007	LYPLA1-011	LYPLA1-012	LYPLA1-013	LYPLA1-015	LYPLA1-201	LYPLA1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYPLA1-001 ENSP00000320043 ENST00000316963	O75608 [Direct mapping] Acyl-protein thioesterase 1 Q6IAQ1 [Target identity:100%; Query identity:100%] LYPLA1 protein; Lysophospholipase I, isoform CRA_a; cDNA FLJ78542, highly similar to Homo sapiens lysophospholipase I (LYPLA1), mRNA; cDNA, FLJ94339, Homo sapiens lysophospholipase I (LYPLA1), mRNA Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002084 [protein depalmitoylation] GO:0004622 [lysophospholipase activity] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006631 [fatty acid metabolic process] GO:0008474 [palmitoyl-(protein) hydrolase activity] GO:0016298 [lipase activity] GO:0016787 [hydrolase activity] GO:0042997 [negative regulation of Golgi to plasma membrane protein transport] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	230 aa 24.7 kDa	No	0
LYPLA1-007 ENSP00000428729 ENST00000518546	E5RGR0 [Direct mapping] Acyl-protein thioesterase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	197 aa 20.9 kDa	No	0
LYPLA1-011 ENSP00000430791 ENST00000521898	E5RI35 [Direct mapping] Acyl-protein thioesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	103 aa 10.7 kDa	No	0
LYPLA1-012 ENSP00000427967 ENST00000522007	E5RFT6 [Direct mapping] Acyl-protein thioesterase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	58 aa 6 kDa	No	1
LYPLA1-013 ENSP00000428306 ENST00000521352	E5RJ48 [Direct mapping] Acyl-protein thioesterase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	90 aa 9.6 kDa	No	0
LYPLA1-015 ENSP00000344477 ENST00000343231	O75608 [Direct mapping] Acyl-protein thioesterase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002084 [protein depalmitoylation] GO:0004622 [lysophospholipase activity] GO:0005829 [cytosol] GO:0006631 [fatty acid metabolic process] GO:0008474 [palmitoyl-(protein) hydrolase activity] GO:0016298 [lipase activity] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0070062 [extracellular exosome] Show all	214 aa 22.9 kDa	No	0
LYPLA1-201 ENSP00000484280 ENST00000618741	A0A087X1K9 [Direct mapping] Acyl-protein thioesterase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	166 aa 18 kDa	No	0
LYPLA1-202 ENSP00000482430 ENST00000618914	B4DP64 [Direct mapping] Acyl-protein thioesterase 1; cDNA FLJ52008, highly similar to Acyl-protein thioesterase 1 (EC 3.1.2.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	196 aa 21.1 kDa	No	0

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The Human Protein Atlas

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