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This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Sep 2009]
Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002215 [defense response to nematode] GO:0004601 [peroxidase activity] GO:0006979 [response to oxidative stress] GO:0020037 [heme binding] GO:0032693 [negative regulation of interleukin-10 production] GO:0032714 [negative regulation of interleukin-5 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0042744 [hydrogen peroxide catabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0072677 [eosinophil migration]
