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TBX2

GENERAL INFORMATION

Gene name

 TBX2

Gene description

 T-box 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lung)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA008586 , CAB013636
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TBX2

Synonyms

Description

 T-box 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q23.2

Chromosome location (bp)

 61399896 - 61409466

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121068 (version 83.38)

Entrez gene

 6909

UniProt

 Q13207 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13207

Antibodypedia

 TBX2 antibodies

PROTEIN BROWSER
TBX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBX2-001
ENSP00000240328
ENST00000240328
Q13207 [Direct mapping]
T-box transcription factor TBX2
A0A024QZ86 [Target identity:100%; Query identity:100%]
T-box 2, isoform CRA_a
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001947 [heart looping]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0007521 [muscle cell fate determination]
GO:0007569 [cell aging]
GO:0008016 [regulation of heart contraction]
GO:0008284 [positive regulation of cell proliferation]
GO:0035050 [embryonic heart tube development]
GO:0035909 [aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0042733 [embryonic digit morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048738 [cardiac muscle tissue development]
GO:0060021 [palate development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060465 [pharynx development]
GO:0060560 [developmental growth involved in morphogenesis]
GO:0060596 [mammary placode formation]
GO:0090398 [cellular senescence]
GO:1901208 [negative regulation of heart looping]
GO:1901211 [negative regulation of cardiac chamber formation]
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 712 aa
75.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.