Cell atlas - NCAPH - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NCAPH
Gene description	Non-SMC condensin I complex, subunit H
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nucleus (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA003008
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleus.

Main location

Cytosol (supported)

Additional location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA003008	A-431	Nucleus	Spatial
HPA003008	A-431	Cytosol	Spatial
HPA003008	U-2 OS	Nucleus	Spatial
HPA003008	U-2 OS	Cytosol	Spatial
HPA003008	U-251 MG	Nucleus	Spatial
HPA003008	U-251 MG	Cytosol	Spatial

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000034906 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA003008	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	NCAPH (HGNC Symbol)
Synonyms	BRRN1, CAP-H, hCAP-H
Description	Non-SMC condensin I complex, subunit H (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	96335787 - 96373845
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121152 (version 83.38)
Entrez gene	23397
UniProt	Q15003 (UniProt - Evidence at protein level)
neXtProt	NX_Q15003
Antibodypedia	NCAPH antibodies

PROTEIN BROWSER

NCAPH-001	NCAPH-002	NCAPH-004	NCAPH-005	NCAPH-006	NCAPH-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPH-001 ENSP00000240423 ENST00000240423	Q15003 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0016020 [membrane] GO:0051301 [cell division] Show all	741 aa 82.6 kDa	No	0
NCAPH-002 ENSP00000400774 ENST00000427946	Q15003 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0016020 [membrane] GO:0051301 [cell division] Show all	605 aa 67.5 kDa	No	0
NCAPH-004 ENSP00000405237 ENST00000435975	C9J470 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0005737 [cytoplasm] GO:0007076 [mitotic chromosome condensation] Show all	608 aa 68.1 kDa	No	0
NCAPH-005 ENSP00000407308 ENST00000455200	E9PHA2 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0005737 [cytoplasm] GO:0007076 [mitotic chromosome condensation] GO:0051301 [cell division] Show all	730 aa 81.6 kDa	No	0
NCAPH-006 ENSP00000415162 ENST00000435349	H7C415 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0007076 [mitotic chromosome condensation] Show all	182 aa 20 kDa	No	0
NCAPH-007 ENSP00000401227 ENST00000456906	C9JZP1 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0007076 [mitotic chromosome condensation] Show all	216 aa 24 kDa	No	0