Expression of IAPP in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Islet amyloid polypeptide

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053194	CAB000352

GENE INFORMATION
Gene name	IAPP (HGNC Symbol)
Synonyms	AMYLIN, DAP, IAP
Description	Islet amyloid polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21354959 - 21379978
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121351 (version 83.38)
Entrez gene	3375
UniProt	P10997 (UniProt - Evidence at protein level)
neXtProt	NX_P10997
Antibodypedia	IAPP antibodies

PROTEIN BROWSER

IAPP-001	IAPP-002	IAPP-003	IAPP-004	IAPP-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IAPP-001 ENSP00000240652 ENST00000240652	P10997 [Direct mapping] Islet amyloid polypeptide A0A024RAU1 [Target identity:100%; Query identity:100%] Islet amyloid polypeptide, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0019233 [sensory perception of pain] GO:0031018 [endocrine pancreas development] GO:0042755 [eating behavior] GO:0042802 [identical protein binding] GO:0043025 [neuronal cell body] GO:0044267 [cellular protein metabolic process] GO:0045596 [negative regulation of cell differentiation] GO:0045779 [negative regulation of bone resorption] Show all	89 aa 9.8 kDa	Yes	0
IAPP-002 ENSP00000445711 ENST00000542023	F5H1F0 [Direct mapping] Islet amyloid polypeptide Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		79 aa 9 kDa	Yes	0
IAPP-003 ENSP00000445980 ENST00000537593	F5H0S1 [Direct mapping] Islet amyloid polypeptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	79 aa 8.6 kDa	Yes	0
IAPP-004 ENSP00000437559 ENST00000535428	H0YF85 [Direct mapping] Islet amyloid polypeptide Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	85 aa 9.4 kDa	No	0
IAPP-005 ENSP00000437357 ENST00000539393	P10997 [Direct mapping] Islet amyloid polypeptide A0A024RAU1 [Target identity:100%; Query identity:100%] Islet amyloid polypeptide, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0031018 [endocrine pancreas development] GO:0042802 [identical protein binding] GO:0044267 [cellular protein metabolic process] Show all	89 aa 9.8 kDa	Yes	0