Expression of BCL2L14 in cancer - Summary - The Human Protein Atlas

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BCL2L14

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

BCL2-like 14 (apoptosis facilitator)

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040665

GENE INFORMATION
Gene name	BCL2L14 (HGNC Symbol)
Synonyms	BCL-G, BCLG
Description	BCL2-like 14 (apoptosis facilitator) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	12049844 - 12211084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121380 (version 83.38)
Entrez gene	79370
UniProt	Q9BZR8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZR8
Antibodypedia	BCL2L14 antibodies

PROTEIN BROWSER

BCL2L14-001	BCL2L14-003	BCL2L14-004	BCL2L14-005	BCL2L14-010	BCL2L14-011	BCL2L14-012	BCL2L14-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2L14-001 ENSP00000309132 ENST00000308721	Q9BZR8 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 A0A024RAR1 [Target identity:100%; Query identity:100%] HCG27697, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042981 [regulation of apoptotic process] GO:0043229 [intracellular organelle] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	327 aa 36.6 kDa	No	0
BCL2L14-003 ENSP00000266434 ENST00000266434	Q9BZR8 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042981 [regulation of apoptotic process] GO:0043229 [intracellular organelle] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	252 aa 28.1 kDa	No	0
BCL2L14-004 ENSP00000417223 ENST00000464885	C9J3S1 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.6 kDa	No	0
BCL2L14-005 ENSP00000419617 ENST00000461264	C9K0Q9 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.1 kDa	No	0
BCL2L14-010 ENSP00000466693 ENST00000586576	K7EMX4 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042981 [regulation of apoptotic process] Show all	360 aa 40.2 kDa	No	0
BCL2L14-011 ENSP00000467086 ENST00000589718	Q9BZR8 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 A0A024RAR1 [Target identity:100%; Query identity:100%] HCG27697, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042981 [regulation of apoptotic process] GO:0043229 [intracellular organelle] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	327 aa 36.6 kDa	No	0
BCL2L14-012 ENSP00000379653 ENST00000396367	Q9BZR8 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 A0A024RAR1 [Target identity:100%; Query identity:100%] HCG27697, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042981 [regulation of apoptotic process] GO:0043229 [intracellular organelle] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	327 aa 36.6 kDa	No	0
BCL2L14-013 ENSP00000465663 ENST00000588270	K7EKK7 [Direct mapping] Apoptosis facilitator Bcl-2-like protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 19.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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