Cell atlas - PSPC1 - The Human Protein Atlas

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PSPC1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleoplasm

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PSPC1
Gene description	Paraspeckle component 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center) & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nucleoli fibrillar center (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038904
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center) & nucleoplasm.

Main location

Nucleoplasm (approved), Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038904	A-431	Nucleoplasm
	HPA038904	U-2 OS	Nucleoplasm
	HPA038904	U-2 OS	Nucleoli fibrillar center	Intensity
	HPA038904	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	PSPC1 (HGNC Symbol)
Synonyms	FLJ10955, PSP1
Description	Paraspeckle component 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	19674752 - 19783019
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121390 (version 83.38)
Entrez gene	55269
UniProt	Q8WXF1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXF1
Antibodypedia	PSPC1 antibodies

PROTEIN BROWSER

PSPC1-002	PSPC1-004	PSPC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSPC1-002 ENSP00000343966 ENST00000338910	Q8WXF1 [Direct mapping] Paraspeckle component 1 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0042382 [paraspeckles] GO:0042752 [regulation of circadian rhythm] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] Show all	523 aa 58.7 kDa	No	0
PSPC1-004 ENSP00000393069 ENST00000427943	X6RDA4 [Direct mapping] Paraspeckle component 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	248 aa 27.3 kDa	No	0
PSPC1-201 ENSP00000481916 ENST00000619300	Q8WXF1 [Direct mapping] Paraspeckle component 1 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0042752 [regulation of circadian rhythm] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] Show all	523 aa 58.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.