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Most cancer cells displayed moderate cytoplasmic staining with additional nuclear positivity in several cases. Urothelial cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PDZRN3 (HGNC Symbol)
Synonyms
KIAA1095, LNX3, SEMACAP3
Description
PDZ domain containing ring finger 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]