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CD80

CANCER ATLAS

Gene description

 CD80 molecule

Protein class

 CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA050092
CAB025368

GENE INFORMATION

Gene name

 CD80 (HGNC Symbol)

Synonyms

 B7-1, B7.1, CD28LG, CD28LG1

Description

 CD80 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

Chromosome

 3

Cytoband

 q13.33

Chromosome location (bp)

 119524293 - 119559602

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121594 (version 83.38)

Entrez gene

 941

UniProt

 P33681 (UniProt - Evidence at protein level)

neXtProt

 NX_P33681

Antibodypedia

 CD80 antibodies

PROTEIN BROWSER
CD80-001
CD80-002
CD80-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD80-001
ENSP00000264246
ENST00000264246
P33681 [Direct mapping]
T-lymphocyte activation antigen CD80
A0N0P2 [Target identity:100%; Query identity:100%]
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), isoform CRA_a; CD80 molecule; cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Show all
GO:0001618 [virus receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0071222 [cellular response to lipopolysaccharide]
Show all
 288 aa
33 kDa 		Yes 1
CD80-002
ENSP00000418364
ENST00000478182
P33681 [Direct mapping]
T-lymphocyte activation antigen CD80
A0N0P2 [Target identity:100%; Query identity:100%]
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), isoform CRA_a; CD80 molecule; cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Show all
GO:0001618 [virus receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
Show all
 288 aa
33 kDa 		Yes 1
CD80-201
ENSP00000373165
ENST00000383669
P33681 [Direct mapping]
T-lymphocyte activation antigen CD80
Show all
CD markers
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Biotech drugs
Show all
GO:0001618 [virus receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
Show all
 256 aa
29.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.