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CRY2

GENERAL INFORMATION

Gene name

 CRY2

Gene description

 Cryptochrome circadian clock 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in a majority of tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037577
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CRY2

Synonyms

Description

 Cryptochrome circadian clock 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 45847118 - 45883248

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121671 (version 83.38)

Entrez gene

 1408

UniProt

 Q49AN0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q49AN0

Antibodypedia

 CRY2 antibodies

PROTEIN BROWSER
CRY2-001
CRY2-002
CRY2-011
CRY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRY2-001
ENSP00000406751
ENST00000443527
A0A0D2X7Z3 [Direct mapping]
Cryptochrome-2
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 614 aa
68.9 kDa 		Yes 0
CRY2-002
ENSP00000397419
ENST00000417225
Q49AN0 [Direct mapping]
Cryptochrome-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009785 [blue light signaling pathway]
GO:0009882 [blue light photoreceptor activity]
GO:0018298 [protein-chromophore linkage]
GO:0019902 [phosphatase binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032922 [circadian regulation of gene expression]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043130 [ubiquitin binding]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071949 [FAD binding]
GO:2000118 [regulation of sodium-dependent phosphate transport]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 532 aa
60.6 kDa 		No 0
CRY2-011
ENSP00000484684
ENST00000616080
Q49AN0 [Direct mapping]
Cryptochrome-2
A2I2P1 [Target identity:100%; Query identity:100%]
Cryptochrome 2 (Photolyase-like), isoform CRA_a; Growth-inhibiting protein 37; Photolyase-like cryptochrome 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009785 [blue light signaling pathway]
GO:0009882 [blue light photoreceptor activity]
GO:0018298 [protein-chromophore linkage]
GO:0019902 [phosphatase binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032922 [circadian regulation of gene expression]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043130 [ubiquitin binding]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071949 [FAD binding]
GO:2000118 [regulation of sodium-dependent phosphate transport]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 593 aa
66.9 kDa 		Yes 0
CRY2-201
ENSP00000478187
ENST00000616623
A0A0D2X7Z3 [Direct mapping]
Cryptochrome-2
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006606 [protein import into nucleus]
GO:0007623 [circadian rhythm]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0032868 [response to insulin]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0071949 [FAD binding]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000850 [negative regulation of glucocorticoid secretion]
Show all
 614 aa
68.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.