Expression of PEX16 in cancer - Summary

CANCER ATLAS

Gene description

Peroxisomal biogenesis factor 16

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043286

GENE INFORMATION
Gene name	PEX16
Synonyms
Description	Peroxisomal biogenesis factor 16 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	45909669 - 45918812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121680 (version 83.38)
Entrez gene	9409
UniProt	Q9Y5Y5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Y5
Antibodypedia	PEX16 antibodies

PROTEIN BROWSER

PEX16-001	PEX16-002	PEX16-003	PEX16-006	PEX16-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX16-001 ENSP00000368024 ENST00000378750	Q9Y5Y5 [Direct mapping] Peroxisomal membrane protein PEX16 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0016557 [peroxisome membrane biogenesis] GO:0016558 [protein import into peroxisome matrix] GO:0022615 [protein to membrane docking] GO:0032581 [ER-dependent peroxisome organization] GO:0045046 [protein import into peroxisome membrane] GO:0070972 [protein localization to endoplasmic reticulum] Show all	336 aa 38.6 kDa	No	1
PEX16-002 ENSP00000241041 ENST00000241041	Q9Y5Y5 [Direct mapping] Peroxisomal membrane protein PEX16 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0016557 [peroxisome membrane biogenesis] GO:0016558 [protein import into peroxisome matrix] GO:0022615 [protein to membrane docking] GO:0032581 [ER-dependent peroxisome organization] GO:0045046 [protein import into peroxisome membrane] GO:0070972 [protein localization to endoplasmic reticulum] Show all	346 aa 39.3 kDa	No	1
PEX16-003 ENSP00000434654 ENST00000532681	E9PP98 [Direct mapping] Peroxisomal membrane protein PEX16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		241 aa 27.8 kDa	No	2
PEX16-006 ENSP00000431309 ENST00000525192	E9PLS4 [Direct mapping] Peroxisomal membrane protein PEX16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		160 aa 18 kDa	No	1
PEX16-007 ENSP00000433045 ENST00000533151	E9PMM3 [Direct mapping] Peroxisomal membrane protein PEX16 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 21.2 kDa	No	0