Cell atlas - GJA3 - The Human Protein Atlas

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GJA3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GJA3
Gene description	Gap junction protein, alpha 3, 46kDa
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (CAPAN-2, HL-60)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, HL-60) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GJA3 (HGNC Symbol)
Synonyms	CX46, CZP3
Description	Gap junction protein, alpha 3, 46kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	20138255 - 20161049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121743 (version 83.38)
Entrez gene	2700
UniProt	Q9Y6H8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6H8
Antibodypedia	GJA3 antibodies

PROTEIN BROWSER

GJA3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJA3-001 ENSP00000241125 ENST00000241125	Q9Y6H8 [Direct mapping] Gap junction alpha-3 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005243 [gap junction channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0007154 [cell communication] GO:0007267 [cell-cell signaling] GO:0007601 [visual perception] GO:0009268 [response to pH] GO:0016021 [integral component of membrane] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0045121 [membrane raft] GO:0055085 [transmembrane transport] Show all	435 aa 47.4 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.