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KHDRBS1

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GENERAL INFORMATION

Gene name

 KHDRBS1

Gene description

 KH domain containing, RNA binding, signal transduction associated 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB005355 , HPA051280 , HPA056813
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ASSAYS
RNA expression
Human cells
siRNA
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051280 A-431 Nucleoplasm
HPA051280 U-2 OS Nucleoplasm
HPA051280 U-251 MG Nucleoplasm
CAB005355 A-431 Nucleoplasm
CAB005355 U-2 OS Nucleoplasm
CAB005355 U-251 MG Nucleoplasm
HPA056813 A-431 Nucleoplasm
HPA056813 U-2 OS Nucleoplasm
HPA056813 U-251 MG Nucleoplasm

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA051280

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 40%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA051280 siRNA 1 U-2 OS
HPA051280 scrambled U-2 OS

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000028790 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA051280 NIH 3T3 Nuclear bodies
HPA056813 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 KHDRBS1 (HGNC Symbol)

Synonyms

 FLJ34027, p62, Sam68

Description

 KH domain containing, RNA binding, signal transduction associated 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 32013829 - 32060850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121774 (version 83.38)

Entrez gene

 10657

UniProt

 Q07666 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07666

Antibodypedia

 KHDRBS1 antibodies

PROTEIN BROWSER
KHDRBS1-001
KHDRBS1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KHDRBS1-001
ENSP00000313829
ENST00000327300
Q07666 [Direct mapping]
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008143 [poly(A) binding]
GO:0008266 [poly(U) RNA binding]
GO:0008283 [cell proliferation]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045948 [positive regulation of translational initiation]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046833 [positive regulation of RNA export from nucleus]
GO:0070618 [Grb2-Sos complex]
Show all
 443 aa
48.2 kDa 		No 0
KHDRBS1-003
ENSP00000417731
ENST00000492989
Q07666 [Direct mapping]
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008143 [poly(A) binding]
GO:0008266 [poly(U) RNA binding]
GO:0008283 [cell proliferation]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045948 [positive regulation of translational initiation]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046833 [positive regulation of RNA export from nucleus]
Show all
 404 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.