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CCR2

GENERAL INFORMATION

Gene name

 CCR2

Gene description

 Chemokine (C-C motif) receptor 2

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB003793
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, lymph node)

GENE INFORMATION

Gene name

 CCR2 (HGNC Symbol)

Synonyms

 CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R

Description

 Chemokine (C-C motif) receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46353734 - 46360928

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121807 (version 83.38)

Entrez gene

 729230

UniProt

 P41597 (UniProt - Evidence at protein level)

neXtProt

 NX_P41597

Antibodypedia

 CCR2 antibodies

PROTEIN BROWSER
CCR2-001
CCR2-002
CCR2-004
CCR2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR2-001
ENSP00000383681
ENST00000400888
P41597 [Direct mapping]
C-C chemokine receptor type 2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0001974 [blood vessel remodeling]
GO:0002407 [dendritic cell chemotaxis]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0002829 [negative regulation of type 2 immune response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007259 [JAK-STAT cascade]
GO:0009611 [response to wounding]
GO:0010574 [regulation of vascular endothelial growth factor production]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019725 [cellular homeostasis]
GO:0030425 [dendrite]
GO:0031727 [CCR2 chemokine receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035705 [T-helper 17 cell chemotaxis]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043310 [negative regulation of eosinophil degranulation]
GO:0045087 [innate immune response]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0050870 [positive regulation of T cell activation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090265 [positive regulation of immune complex clearance by monocytes and macrophages]
GO:2000439 [positive regulation of monocyte extravasation]
GO:2000451 [positive regulation of CD8-positive, alpha-beta T cell extravasation]
GO:2000464 [positive regulation of astrocyte chemotaxis]
GO:2000473 [positive regulation of hematopoietic stem cell migration]
Show all
 374 aa
41.9 kDa 		No 6
CCR2-002
ENSP00000399285
ENST00000445132
P41597 [Direct mapping]
C-C chemokine receptor type 2
A0A024R2Q0 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 2, isoform CRA_a
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001974 [blood vessel remodeling]
GO:0002407 [dendritic cell chemotaxis]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0002829 [negative regulation of type 2 immune response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007259 [JAK-STAT cascade]
GO:0009611 [response to wounding]
GO:0010574 [regulation of vascular endothelial growth factor production]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019725 [cellular homeostasis]
GO:0030425 [dendrite]
GO:0031727 [CCR2 chemokine receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035705 [T-helper 17 cell chemotaxis]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043310 [negative regulation of eosinophil degranulation]
GO:0045087 [innate immune response]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050729 [positive regulation of inflammatory response]
GO:0050870 [positive regulation of T cell activation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090265 [positive regulation of immune complex clearance by monocytes and macrophages]
GO:2000439 [positive regulation of monocyte extravasation]
GO:2000451 [positive regulation of CD8-positive, alpha-beta T cell extravasation]
GO:2000464 [positive regulation of astrocyte chemotaxis]
GO:2000473 [positive regulation of hematopoietic stem cell migration]
Show all
 360 aa
41.1 kDa 		No 7
CCR2-004
ENSP00000396736
ENST00000421659
E9PH76 [Direct mapping]
C-C chemokine receptor type 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0001974 [blood vessel remodeling]
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0090026 [positive regulation of monocyte chemotaxis]
Show all
 121 aa
13.7 kDa 		No 2
CCR2-201
ENSP00000292301
ENST00000292301
P41597 [Direct mapping]
C-C chemokine receptor type 2
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0001974 [blood vessel remodeling]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0002829 [negative regulation of type 2 immune response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007259 [JAK-STAT cascade]
GO:0007568 [aging]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0010212 [response to ionizing radiation]
GO:0010574 [regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019725 [cellular homeostasis]
GO:0019901 [protein kinase binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0030425 [dendrite]
GO:0030517 [negative regulation of axon extension]
GO:0030900 [forebrain development]
GO:0031622 [positive regulation of fever generation]
GO:0031727 [CCR2 chemokine receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035705 [T-helper 17 cell chemotaxis]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043310 [negative regulation of eosinophil degranulation]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050870 [positive regulation of T cell activation]
GO:0060139 [positive regulation of apoptotic process by virus]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070997 [neuron death]
GO:0071791 [chemokine (C-C motif) ligand 5 binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090265 [positive regulation of immune complex clearance by monocytes and macrophages]
GO:2000178 [negative regulation of neural precursor cell proliferation]
GO:2000439 [positive regulation of monocyte extravasation]
GO:2000451 [positive regulation of CD8-positive, alpha-beta T cell extravasation]
GO:2000464 [positive regulation of astrocyte chemotaxis]
GO:2000473 [positive regulation of hematopoietic stem cell migration]
Show all
 374 aa
41.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.