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GHSR

GENERAL INFORMATION

Gene name

 GHSR

Gene description

 Growth hormone secretagogue receptor

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. External RNA data suggests expression in pituitary gland. No internal RNA expression data available for correlation.

Reliability score

 Uncertain based on 1 antibody.
CAB012451
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION

Gene name

 GHSR

Synonyms

Description

 Growth hormone secretagogue receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

Chromosome

 3

Cytoband

 q26.31

Chromosome location (bp)

 172445133 - 172448456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121853 (version 83.38)

Entrez gene

 2693

UniProt

 Q92847 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92847

Antibodypedia

 GHSR antibodies

PROTEIN BROWSER
GHSR-001
GHSR-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GHSR-001
ENSP00000241256
ENST00000241256
Q92847 [Direct mapping]
Growth hormone secretagogue receptor type 1
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001616 [growth hormone secretagogue receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008154 [actin polymerization or depolymerization]
GO:0008343 [adult feeding behavior]
GO:0009725 [response to hormone]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016520 [growth hormone-releasing hormone receptor activity]
GO:0017046 [peptide hormone binding]
GO:0030252 [growth hormone secretion]
GO:0032094 [response to food]
GO:0032100 [positive regulation of appetite]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032869 [cellular response to insulin stimulus]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042536 [negative regulation of tumor necrosis factor biosynthetic process]
GO:0042562 [hormone binding]
GO:0043005 [neuron projection]
GO:0043134 [regulation of hindgut contraction]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0045121 [membrane raft]
GO:0045409 [negative regulation of interleukin-6 biosynthetic process]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046697 [decidualization]
GO:0050728 [negative regulation of inflammatory response]
GO:0051963 [regulation of synapse assembly]
Show all
 366 aa
41.3 kDa 		No 7
GHSR-002
ENSP00000395344
ENST00000427970
Q92847 [Direct mapping]
Growth hormone secretagogue receptor type 1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001616 [growth hormone secretagogue receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008154 [actin polymerization or depolymerization]
GO:0008343 [adult feeding behavior]
GO:0009725 [response to hormone]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016520 [growth hormone-releasing hormone receptor activity]
GO:0030252 [growth hormone secretion]
GO:0032100 [positive regulation of appetite]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042536 [negative regulation of tumor necrosis factor biosynthetic process]
GO:0043005 [neuron projection]
GO:0045121 [membrane raft]
GO:0045409 [negative regulation of interleukin-6 biosynthetic process]
GO:0046697 [decidualization]
GO:0050728 [negative regulation of inflammatory response]
Show all
 289 aa
32.2 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.