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Gliomas, thyroid and prostate cancers along with a few cases of melanomas, colorectal, breast, lung and testicular cancers showed moderate to strong cytoplasmic positivity and membranous positivity in several cases. Remaining cancers were generally negative.
GENE INFORMATION
Gene name
TNFSF10 (HGNC Symbol)
Synonyms
Apo-2L, CD253, TL2, TRAIL
Description
Tumor necrosis factor (ligand) superfamily, member 10 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]