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A majority of malignancies showed weak to moderate cytoplasmic staining. A few cases of skin and urothelial cancer displayed strong cytoplasmic positivity. Several hepatocellular carcinomas, malignant lymphomas, melanomas and ovarian cancers were generally negative.
Most malignant cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern.
GENE INFORMATION
Gene name
GPSM2 (HGNC Symbol)
Synonyms
DFNB82, LGN, Pins
Description
G-protein signaling modulator 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]