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ACVR2A

CANCER ATLAS

Gene description

 Activin A receptor, type IIA

Protein class

 Cancer-related genes, Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046997

GENE INFORMATION

Gene name

 ACVR2A (HGNC Symbol)

Synonyms

 ACTRII, ACVR2

Description

 Activin A receptor, type IIA (HGNC Symbol)

Entrez gene summary

 This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Chromosome

 2

Cytoband

Chromosome location (bp)

 147844517 - 147930826

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121989 (version 83.38)

Entrez gene

 92

UniProt

 P27037 (UniProt - Evidence at protein level)

neXtProt

 NX_P27037

Antibodypedia

 ACVR2A antibodies

PROTEIN BROWSER
ACVR2A-001
ACVR2A-002
ACVR2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACVR2A-001
ENSP00000241416
ENST00000241416
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001702 [gastrulation with mouth forming second]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007368 [determination of left/right symmetry]
GO:0007498 [mesoderm development]
GO:0008584 [male gonad development]
GO:0009952 [anterior/posterior pattern specification]
GO:0009966 [regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017002 [activin-activated receptor activity]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030165 [PDZ domain binding]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030510 [regulation of BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034711 [inhibin binding]
GO:0042713 [sperm ejaculation]
GO:0043084 [penile erection]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048706 [embryonic skeletal system development]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0060011 [Sertoli cell proliferation]
GO:0071773 [cellular response to BMP stimulus]
Show all
 513 aa
57.8 kDa 		Yes 1
ACVR2A-002
ENSP00000384338
ENST00000404590
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017002 [activin-activated receptor activity]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0071773 [cellular response to BMP stimulus]
Show all
 513 aa
57.8 kDa 		Yes 1
ACVR2A-201
ENSP00000439988
ENST00000535787
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0017002 [activin-activated receptor activity]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0071773 [cellular response to BMP stimulus]
Show all
 405 aa
45.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.