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MTIF3

GENERAL INFORMATION

Gene name

 MTIF3

Gene description

 Mitochondrial translational initiation factor 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039791
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MTIF3 (HGNC Symbol)

Synonyms

 IF-3mt, IF3(mt)

Description

 Mitochondrial translational initiation factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

Chromosome

 13

Cytoband

 q12.2

Chromosome location (bp)

 27435643 - 27450591

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122033 (version 83.38)

Entrez gene

 219402

UniProt

 Q9H2K0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2K0

Antibodypedia

 MTIF3 antibodies

PROTEIN BROWSER
MTIF3-010
MTIF3-011
MTIF3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTIF3-010
ENSP00000370508
ENST00000381116
Q9H2K0 [Direct mapping]
Translation initiation factor IF-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0070124 [mitochondrial translational initiation]
Show all
 278 aa
31.7 kDa 		No 0
MTIF3-011
ENSP00000370512
ENST00000381120
Q9H2K0 [Direct mapping]
Translation initiation factor IF-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0070124 [mitochondrial translational initiation]
Show all
 278 aa
31.7 kDa 		No 0
MTIF3-201
ENSP00000384659
ENST00000405591
Q9H2K0 [Direct mapping]
Translation initiation factor IF-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0070124 [mitochondrial translational initiation]
Show all
 278 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.