Cell atlas - GTF3A - The Human Protein Atlas

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GTF3A

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GTF3A
Gene description	General transcription factor IIIA
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA007990
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007990	A-431	Nucleoplasm
	HPA007990	U-2 OS	Nucleus
	HPA007990	U-251 MG	Nucleus

GENE INFORMATION
Gene name	GTF3A (HGNC Symbol)
Synonyms	AP2, TFIIIA
Description	General transcription factor IIIA (HGNC Symbol)
Entrez gene summary	The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.2
Chromosome location (bp)	27424544 - 27435823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122034 (version 83.38)
Entrez gene	2971
UniProt	Q92664 (UniProt - Evidence at protein level)
neXtProt	NX_Q92664
Antibodypedia	GTF3A antibodies

PROTEIN BROWSER

GTF3A-001	GTF3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTF3A-001 ENSP00000370532 ENST00000381140	Q92664 [Direct mapping] Transcription factor IIIA Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0009303 [rRNA transcription] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	365 aa 41.5 kDa	No	0
GTF3A-201 ENSP00000393050 ENST00000439403	B7ZBK4 [Direct mapping] Transcription factor IIIA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	422 aa 46.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.