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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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XPNPEP2
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  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

XPNPEP2

Gene description

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (small intestine, kidney, duodenum)
GTEx:Group enriched (small intestine, kidney)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

Evidence at protein level

Protein expression

Luminal membranous expression in renal tubules and intestinal glands.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA000339 , CAB025136 , CAB025269
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, kidney, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

XPNPEP2

Synonyms

Description

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (HGNC Symbol)

Entrez gene summary

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q26.1

Chromosome location (bp)

129738974 - 129769538

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122121 (version 83.38)

Entrez gene

7512

UniProt

O43895 (UniProt - Evidence at transcript level)

neXtProt

NX_O43895

Antibodypedia

XPNPEP2 antibodies

PROTEIN BROWSER

XPNPEP2-001
XPNPEP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

XPNPEP2-001
ENSP00000360147
ENST00000371106
O43895 [Direct mapping]
Xaa-Pro aminopeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0031225 [anchored component of membrane]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
674 aa
75.6 kDa
Yes 0
XPNPEP2-002
ENSP00000360146
ENST00000371105
Q5JZ40 [Direct mapping]
Xaa-Pro aminopeptidase 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
183 aa
20.4 kDa
Yes 0

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The Human Protein Atlas project is funded
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