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HNRNPA2B1

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GENERAL INFORMATION

Gene name

 HNRNPA2B1

Gene description

 Heterogeneous nuclear ribonucleoprotein A2/B1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
HPA005812 , CAB012403 , HPA065537
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB012403 A-431 Nucleoplasm
CAB012403 U-2 OS Nucleoplasm
CAB012403 U-251 MG Nucleoplasm
HPA005812 A549 Nucleoplasm
HPA005812 PC-3 Nucleoplasm
HPA005812 U-2 OS Nucleoplasm
HPA065537 PC-3 Nucleoplasm
HPA065537 SH-SY5Y Nucleoplasm
HPA065537 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 HNRNPA2B1 (HGNC Symbol)

Synonyms

 HNRPA2B1

Description

 Heterogeneous nuclear ribonucleoprotein A2/B1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 26189927 - 26201529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122566 (version 83.38)

Entrez gene

 3181

UniProt

 P22626 (UniProt - Evidence at protein level)

neXtProt

 NX_P22626

Antibodypedia

 HNRNPA2B1 antibodies

PROTEIN BROWSER
HNRNPA2B1-001
HNRNPA2B1-002
HNRNPA2B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNRNPA2B1-001
ENSP00000346694
ENST00000354667
P22626 [Direct mapping]
Heterogeneous nuclear ribonucleoproteins A2/B1
A0A024RA61 [Target identity:100%; Query identity:100%]
Heterogeneous nuclear ribonucleoprotein A2/B1, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0043047 [single-stranded telomeric DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050658 [RNA transport]
GO:0071013 [catalytic step 2 spliceosome]
GO:0097157 [pre-mRNA intronic binding]
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 353 aa
37.4 kDa 		No 0
HNRNPA2B1-002
ENSP00000349101
ENST00000356674
P22626 [Direct mapping]
Heterogeneous nuclear ribonucleoproteins A2/B1
A0A024RA27 [Target identity:100%; Query identity:100%]
Heterogeneous nuclear ribonucleoprotein A2/B1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0043047 [single-stranded telomeric DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0050658 [RNA transport]
GO:0071013 [catalytic step 2 spliceosome]
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 341 aa
36 kDa 		No 0
HNRNPA2B1-201
ENSP00000478691
ENST00000618183
A0A087WUI2 [Direct mapping]
Heterogeneous nuclear ribonucleoproteins A2/B1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 261 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.