Cell atlas - HOXA7 - The Human Protein Atlas

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HOXA7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoplasm

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HOXA7
Gene description	Homeobox A7
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear membrane.
RNA cell category	Cell line enhanced (SCLC-21H, RPTEC TERT1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA074048
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear membrane.

Main location

Nucleoplasm (approved)

Additional location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074048	SiHa	Nucleoplasm
	HPA074048	SiHa	Nuclear membrane
	HPA074048	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	HOXA7 (HGNC Symbol)
Synonyms	HOX1, HOX1A
Description	Homeobox A7 (HGNC Symbol)
Entrez gene summary	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p15.2
Chromosome location (bp)	27153716 - 27157936
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000122592 (version 83.38)
Entrez gene	3204
UniProt	P31268 (UniProt - Evidence at transcript level)
neXtProt	NX_P31268
Antibodypedia	HOXA7 antibodies

PROTEIN BROWSER

HOXA7-001	HOXA7-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXA7-001 ENSP00000242159 ENST00000242159	P31268 [Direct mapping] Homeobox protein Hox-A7 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001525 [angiogenesis] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0002686 [negative regulation of leukocyte migration] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0009952 [anterior/posterior pattern specification] GO:0043565 [sequence-specific DNA binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048863 [stem cell differentiation] Show all	230 aa 25.4 kDa	No	0
HOXA7-002 ENSP00000428563 ENST00000519842	E5RHM9 [Direct mapping] Homeobox protein Hox-A7 Show all	Predicted intracellular proteins Show all		30 aa 3.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.