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ACO1

CANCER ATLAS

Gene description

 Aconitase 1, soluble

Protein class

 Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA019371
HPA024157

GENE INFORMATION

Gene name

 ACO1 (HGNC Symbol)

Synonyms

 IREB1, IREBP, IRP1

Description

 Aconitase 1, soluble (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Chromosome

 9

Cytoband

 p21.1

Chromosome location (bp)

 32384603 - 32454769

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122729 (version 83.38)

Entrez gene

 48

UniProt

 P21399 (UniProt - Evidence at protein level)

neXtProt

 NX_P21399

Antibodypedia

 ACO1 antibodies

PROTEIN BROWSER
ACO1-001
ACO1-002
ACO1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACO1-001
ENSP00000309477
ENST00000309951
P21399 [Direct mapping]
Cytoplasmic aconitate hydratase
V9HWB7 [Target identity:100%; Query identity:100%]
Aconitate hydratase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003994 [aconitate hydratase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006099 [tricarboxylic acid cycle]
GO:0006101 [citrate metabolic process]
GO:0006417 [regulation of translation]
GO:0006879 [cellular iron ion homeostasis]
GO:0008152 [metabolic process]
GO:0009791 [post-embryonic development]
GO:0010040 [response to iron(II) ion]
GO:0010468 [regulation of gene expression]
GO:0030350 [iron-responsive element binding]
GO:0046872 [metal ion binding]
GO:0050892 [intestinal absorption]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 889 aa
98.4 kDa 		No 0
ACO1-002
ENSP00000369255
ENST00000379923
P21399 [Direct mapping]
Cytoplasmic aconitate hydratase
V9HWB7 [Target identity:100%; Query identity:100%]
Aconitate hydratase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003994 [aconitate hydratase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006099 [tricarboxylic acid cycle]
GO:0006101 [citrate metabolic process]
GO:0008152 [metabolic process]
GO:0010040 [response to iron(II) ion]
GO:0030350 [iron-responsive element binding]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 889 aa
98.4 kDa 		No 0
ACO1-201
ENSP00000438733
ENST00000541043
P21399 [Direct mapping]
Cytoplasmic aconitate hydratase
V9HWB7 [Target identity:100%; Query identity:100%]
Aconitate hydratase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003994 [aconitate hydratase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006099 [tricarboxylic acid cycle]
GO:0006101 [citrate metabolic process]
GO:0008152 [metabolic process]
GO:0010040 [response to iron(II) ion]
GO:0030350 [iron-responsive element binding]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 889 aa
98.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.