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SRGN

CANCER ATLAS

Gene description

 Serglycin

Protein class

 Plasma proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000759

GENE INFORMATION

Gene name

 SRGN (HGNC Symbol)

Synonyms

 PPG, PRG, PRG1

Description

 Serglycin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 69088106 - 69104811

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122862 (version 83.38)

Entrez gene

 5552

UniProt

 P10124 (UniProt - Evidence at protein level)

neXtProt

 NX_P10124

Antibodypedia

 SRGN antibodies

PROTEIN BROWSER
SRGN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRGN-001
ENSP00000242465
ENST00000242465
P10124 [Direct mapping]
Serglycin
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
GO:0030141 [secretory granule]
GO:0030168 [platelet activation]
GO:0030502 [negative regulation of bone mineralization]
GO:0031093 [platelet alpha granule lumen]
GO:0031214 [biomineral tissue development]
GO:0033364 [mast cell secretory granule organization]
GO:0033368 [protease localization to mast cell secretory granule]
GO:0033371 [T cell secretory granule organization]
GO:0033373 [maintenance of protease location in mast cell secretory granule]
GO:0033382 [maintenance of granzyme B location in T cell secretory granule]
GO:0042588 [zymogen granule]
GO:0042629 [mast cell granule]
GO:0050710 [negative regulation of cytokine secretion]
Show all
 158 aa
17.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.