Fields »
ABOUT
HELP
BLOG
P4HA1

GENERAL INFORMATION

Gene name

 P4HA1

Gene description

 Prolyl 4-hydroxylase, alpha polypeptide I

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Additional positivity in endothelial cells and extracellular matrix.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA007599 , HPA026593
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 P4HA1 (HGNC Symbol)

Synonyms

 C-P4Halpha(I), P4HA

Description

 Prolyl 4-hydroxylase, alpha polypeptide I (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 73007217 - 73096974

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122884 (version 83.38)

Entrez gene

 5033

UniProt

 P13674 (UniProt - Evidence at protein level)

neXtProt

 NX_P13674

Antibodypedia

 P4HA1 antibodies

PROTEIN BROWSER
P4HA1-001
P4HA1-002
P4HA1-201
P4HA1-202
P4HA1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P4HA1-001
ENSP00000307318
ENST00000307116
P13674 [Direct mapping]
Prolyl 4-hydroxylase subunit alpha-1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004656 [procollagen-proline 4-dioxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031418 [L-ascorbic acid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 534 aa
61 kDa 		Yes 0
P4HA1-002
ENSP00000362099
ENST00000373008
P13674 [Direct mapping]
Prolyl 4-hydroxylase subunit alpha-1
Q5VSQ6 [Target identity:100%; Query identity:100%]
Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I variant; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_a; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004656 [procollagen-proline 4-dioxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031418 [L-ascorbic acid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 534 aa
61 kDa 		Yes 0
P4HA1-201
ENSP00000263556
ENST00000263556
P13674 [Direct mapping]
Prolyl 4-hydroxylase subunit alpha-1
Q5VSQ6 [Target identity:100%; Query identity:100%]
Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I variant; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_a; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004656 [procollagen-proline 4-dioxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0016020 [membrane]
GO:0016222 [procollagen-proline 4-dioxygenase complex]
GO:0016491 [oxidoreductase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0030199 [collagen fibril organization]
GO:0031418 [L-ascorbic acid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 534 aa
61 kDa 		Yes 0
P4HA1-202
ENSP00000378353
ENST00000394890
P13674 [Direct mapping]
Prolyl 4-hydroxylase subunit alpha-1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004656 [procollagen-proline 4-dioxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031418 [L-ascorbic acid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 534 aa
61 kDa 		Yes 0
P4HA1-203
ENSP00000414464
ENST00000440381
P13674 [Direct mapping]
Prolyl 4-hydroxylase subunit alpha-1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004656 [procollagen-proline 4-dioxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031418 [L-ascorbic acid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 516 aa
59 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.