Cell atlas - CDKN2C - The Human Protein Atlas

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CDKN2C

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDKN2C
Gene description	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB018398
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB018398	A-431	Nucleoplasm
	CAB018398	A-431	Cytosol
	CAB018398	U-2 OS	Nucleoplasm
	CAB018398	U-2 OS	Cytosol
	CAB018398	U-251 MG	Nucleoplasm
	CAB018398	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CDKN2C (HGNC Symbol)
Synonyms	INK4C, p18
Description	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	50960745 - 50974633
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123080 (version 83.38)
Entrez gene	1031
UniProt	P42773 (UniProt - Evidence at protein level)
neXtProt	NX_P42773
Antibodypedia	CDKN2C antibodies

PROTEIN BROWSER

CDKN2C-001	CDKN2C-002	CDKN2C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKN2C-001 ENSP00000262662 ENST00000262662	P42773 [Direct mapping] Cyclin-dependent kinase 4 inhibitor C Q6ICV4 [Target identity:100%; Query identity:100%] CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Large Deletions Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0019901 [protein kinase binding] GO:0030308 [negative regulation of cell growth] GO:0042326 [negative regulation of phosphorylation] GO:0048709 [oligodendrocyte differentiation] GO:0071901 [negative regulation of protein serine/threonine kinase activity] Show all	168 aa 18.1 kDa	No	0
CDKN2C-002 ENSP00000360826 ENST00000371761	P42773 [Direct mapping] Cyclin-dependent kinase 4 inhibitor C Q6ICV4 [Target identity:100%; Query identity:100%] CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Large Deletions Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0019901 [protein kinase binding] GO:0030308 [negative regulation of cell growth] GO:0042326 [negative regulation of phosphorylation] GO:0071901 [negative regulation of protein serine/threonine kinase activity] Show all	168 aa 18.1 kDa	No	0
CDKN2C-201 ENSP00000379452 ENST00000396148	P42773 [Direct mapping] Cyclin-dependent kinase 4 inhibitor C Q6ICV4 [Target identity:100%; Query identity:100%] CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Large Deletions Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0019901 [protein kinase binding] GO:0030308 [negative regulation of cell growth] GO:0042326 [negative regulation of phosphorylation] GO:0071901 [negative regulation of protein serine/threonine kinase activity] Show all	168 aa 18.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.