Cell atlas - SSPN - The Human Protein Atlas

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SSPN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SSPN
Gene description	Sarcospan
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the nucleus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066432
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the nucleus.

Main location

Nuclear membrane (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066432	RH-30	Nuclear membrane
	HPA066432	SH-SY5Y	Nuclear membrane
	HPA066432	U-2 OS	Nucleus	Intensity
	HPA066432	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	SSPN (HGNC Symbol)
Synonyms	KRAG, SPN1, SPN2
Description	Sarcospan (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	26121991 - 26299290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123096 (version 83.38)
Entrez gene	8082
UniProt	Q14714 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14714
Antibodypedia	SSPN antibodies

PROTEIN BROWSER

SSPN-001	SSPN-003	SSPN-007	SSPN-008	SSPN-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSPN-001 ENSP00000242729 ENST00000242729	Q14714 [Direct mapping] Sarcospan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030133 [transport vesicle] GO:0042383 [sarcolemma] GO:0045211 [postsynaptic membrane] Show all	243 aa 26.6 kDa	No	4
SSPN-003 ENSP00000396087 ENST00000422622	Q14714 [Direct mapping] Sarcospan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030133 [transport vesicle] GO:0042383 [sarcolemma] GO:0045211 [postsynaptic membrane] Show all	140 aa 15.8 kDa	No	1
SSPN-007 ENSP00000445360 ENST00000538142	F5H381 [Direct mapping] Sarcospan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016021 [integral component of membrane] Show all	120 aa 13.6 kDa	No	1
SSPN-008 ENSP00000438801 ENST00000535504	F5H0K2 [Direct mapping] Sarcospan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016021 [integral component of membrane] Show all	128 aa 13.8 kDa	No	2
SSPN-009 ENSP00000442893 ENST00000540266	Q14714 [Direct mapping] Sarcospan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030133 [transport vesicle] GO:0042383 [sarcolemma] GO:0045211 [postsynaptic membrane] Show all	140 aa 15.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.