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DDX39A

GENERAL INFORMATION

Gene name

 DDX39A

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA055334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX39A (HGNC Symbol)

Synonyms

 BAT1L, DDX39, DDXL, URH49

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14408819 - 14419383

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123136 (version 83.38)

Entrez gene

 10212

UniProt

 O00148 (UniProt - Evidence at protein level)

neXtProt

 NX_O00148

Antibodypedia

 DDX39A antibodies

PROTEIN BROWSER
DDX39A-001
DDX39A-007
DDX39A-008
DDX39A-009
DDX39A-010
DDX39A-012
DDX39A-015
DDX39A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX39A-001
ENSP00000242776
ENST00000242776
O00148 [Direct mapping]
ATP-dependent RNA helicase DDX39A
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
Show all
 427 aa
49.1 kDa 		No 0
DDX39A-007
ENSP00000466810
ENST00000590239
K7EN69 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 130 aa
14.4 kDa 		No 0
DDX39A-008
ENSP00000465926
ENST00000591275
K7EL56 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 108 aa
11.9 kDa 		No 0
DDX39A-009
ENSP00000467040
ENST00000590696
K7ENP6 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 92 aa
10.2 kDa 		No 0
DDX39A-010
ENSP00000464801
ENST00000586993
K7EIL8 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 125 aa
13.8 kDa 		No 0
DDX39A-012
ENSP00000467911
ENST00000589675
K7EQN7 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 255 aa
28.8 kDa 		No 0
DDX39A-015
ENSP00000467411
ENST00000590315
K7EPJ3 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0005681 [spliceosomal complex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 189 aa
21.3 kDa 		No 0
DDX39A-201
ENSP00000392929
ENST00000454233
O00148 [Direct mapping]
ATP-dependent RNA helicase DDX39A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
Show all
 267 aa
30.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.