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WDR83

CANCER ATLAS

Gene description

 WD repeat domain 83

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042629
HPA042838

GENE INFORMATION

Gene name

 WDR83 (HGNC Symbol)

Synonyms

 MORG1

Description

 WD repeat domain 83 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12666800 - 12675832

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123154 (version 83.38)

Entrez gene

 84292

UniProt

 Q9BRX9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BRX9

Antibodypedia

 WDR83 antibodies

PROTEIN BROWSER
WDR83-001
WDR83-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR83-001
ENSP00000402653
ENST00000418543
Q9BRX9 [Direct mapping]
WD repeat domain-containing protein 83
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0071013 [catalytic step 2 spliceosome]
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 315 aa
34.3 kDa 		No 0
WDR83-010
ENSP00000449257
ENST00000547797
H0YIE8 [Direct mapping]
WD repeat domain-containing protein 83
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 211 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.