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GIPC1

GENERAL INFORMATION

Gene name

 GIPC1

Gene description

 GIPC PDZ domain containing family, member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA043958
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GIPC1 (HGNC Symbol)

Synonyms

 C19orf3, GIPC, GLUT1CBP, Hs.6454, NIP, RGS19IP1, SEMCAP, SYNECTIN, TIP-2

Description

 GIPC PDZ domain containing family, member 1 (HGNC Symbol)

Entrez gene summary

 GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14477760 - 14496149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123159 (version 83.38)

Entrez gene

 10755

UniProt

 O14908 (UniProt - Evidence at protein level)

neXtProt

 NX_O14908

Antibodypedia

 GIPC1 antibodies

PROTEIN BROWSER
GIPC1-001
GIPC1-004
GIPC1-005
GIPC1-006
GIPC1-007
GIPC1-008
GIPC1-009
GIPC1-011
GIPC1-012
GIPC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GIPC1-001
ENSP00000376753
ENST00000393033
O14908 [Direct mapping]
PDZ domain-containing protein GIPC1
A0A024R7I0 [Target identity:100%; Query identity:100%]
GIPC PDZ domain containing family, member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005903 [brush border]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017022 [myosin binding]
GO:0030139 [endocytic vesicle]
GO:0030165 [PDZ domain binding]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043542 [endothelial cell migration]
GO:0048167 [regulation of synaptic plasticity]
GO:0070062 [extracellular exosome]
Show all
 333 aa
36 kDa 		No 0
GIPC1-004
ENSP00000464879
ENST00000587969
K7EIT0 [Direct mapping]
PDZ domain-containing protein GIPC1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 121 aa
13.6 kDa 		No 0
GIPC1-005
ENSP00000466747
ENST00000586027
O14908 [Direct mapping]
PDZ domain-containing protein GIPC1
A0A024R7I0 [Target identity:100%; Query identity:100%]
GIPC PDZ domain containing family, member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017022 [myosin binding]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043542 [endothelial cell migration]
GO:0048167 [regulation of synaptic plasticity]
GO:0070062 [extracellular exosome]
Show all
 333 aa
36 kDa 		No 0
GIPC1-006
ENSP00000467077
ENST00000591349
O14908 [Direct mapping]
PDZ domain-containing protein GIPC1
A0A024R7I1 [Target identity:100%; Query identity:100%]
GIPC PDZ domain containing family, member 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017022 [myosin binding]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043542 [endothelial cell migration]
GO:0048167 [regulation of synaptic plasticity]
GO:0070062 [extracellular exosome]
Show all
 236 aa
26.1 kDa 		No 0
GIPC1-007
ENSP00000340698
ENST00000345425
O14908 [Direct mapping]
PDZ domain-containing protein GIPC1
A0A024R7I0 [Target identity:100%; Query identity:100%]
GIPC PDZ domain containing family, member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017022 [myosin binding]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043542 [endothelial cell migration]
GO:0048167 [regulation of synaptic plasticity]
GO:0070062 [extracellular exosome]
Show all
 333 aa
36 kDa 		No 0
GIPC1-008
ENSP00000468787
ENST00000587210
K7ESN1 [Direct mapping]
PDZ domain-containing protein GIPC1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 159 aa
17.5 kDa 		No 0
GIPC1-009
ENSP00000466624
ENST00000587934
K7ELJ2 [Direct mapping]
PDZ domain-containing protein GIPC1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
3.9 kDa 		No 0
GIPC1-011
ENSP00000466105
ENST00000591245
K7ELJ2 [Direct mapping]
PDZ domain-containing protein GIPC1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
3.9 kDa 		No 0
GIPC1-012
ENSP00000466312
ENST00000589631
K7EM11 [Direct mapping]
PDZ domain-containing protein GIPC1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 128 aa
14 kDa 		No 0
GIPC1-201
ENSP00000376748
ENST00000393028
O14908 [Direct mapping]
PDZ domain-containing protein GIPC1
A0A024R7I1 [Target identity:100%; Query identity:100%]
GIPC PDZ domain containing family, member 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008021 [synaptic vesicle]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017022 [myosin binding]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031647 [regulation of protein stability]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043542 [endothelial cell migration]
GO:0048167 [regulation of synaptic plasticity]
GO:0070062 [extracellular exosome]
Show all
 236 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.