Cell atlas - NLN - The Human Protein Atlas

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NLN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	NLN
Gene description	Neurolysin (metallopeptidase M3 family)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031862
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031862	A-431	Mitochondria	Intensity
	HPA031862	U-2 OS	Mitochondria	Intensity
	HPA031862	U-251 MG	Mitochondria	Intensity

GENE INFORMATION
Gene name	NLN (HGNC Symbol)
Synonyms	AGTBP, KIAA1226
Description	Neurolysin (metallopeptidase M3 family) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	65722196 - 65871725
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123213 (version 83.38)
Entrez gene	57486
UniProt	Q9BYT8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYT8
Antibodypedia	NLN antibodies

PROTEIN BROWSER

NLN-001	NLN-003	NLN-009	NLN-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLN-001 ENSP00000370372 ENST00000380985	Q9BYT8 [Direct mapping] Neurolysin, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006111 [regulation of gluconeogenesis] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0042277 [peptide binding] GO:0046872 [metal ion binding] GO:0070012 [oligopeptidase activity] GO:1902809 [regulation of skeletal muscle fiber differentiation] Show all	704 aa 80.7 kDa	No	0
NLN-003 ENSP00000427417 ENST00000511299	H0YAK4 [Direct mapping] Neurolysin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	414 aa 46.9 kDa	No	0
NLN-009 ENSP00000426959 ENST00000509935	H0YAF7 [Direct mapping] Neurolysin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] Show all	283 aa 31.7 kDa	No	0
NLN-010 ENSP00000423214 ENST00000502464	E9PCB6 [Direct mapping] Neurolysin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	600 aa 68.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.