Fields »
ABOUT
HELP
BLOG
OPTN

CANCER ATLAS

Gene description

 Optineurin

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003279
HPA003360
CAB019303

GENE INFORMATION

Gene name

 OPTN (HGNC Symbol)

Synonyms

 FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP

Description

 Optineurin (HGNC Symbol)

Entrez gene summary

 This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p13

Chromosome location (bp)

 13099449 - 13138308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123240 (version 83.38)

Entrez gene

 10133

UniProt

 Q96CV9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96CV9

Antibodypedia

 OPTN antibodies

PROTEIN BROWSER
OPTN-001
OPTN-004
OPTN-005
OPTN-006
OPTN-007
OPTN-008
OPTN-009
OPTN-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OPTN-001
ENSP00000400356
ENST00000424614
H7C1H4 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070530 [K63-linked polyubiquitin binding]
Show all
 126 aa
13.8 kDa 		No 0
OPTN-004
ENSP00000368027
ENST00000378752
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 571 aa
65.2 kDa 		No 0
OPTN-005
ENSP00000368022
ENST00000378748
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0034613 [cellular protein localization]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 577 aa
65.9 kDa 		No 0
OPTN-006
ENSP00000263036
ENST00000263036
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 577 aa
65.9 kDa 		No 0
OPTN-007
ENSP00000368032
ENST00000378757
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 577 aa
65.9 kDa 		No 0
OPTN-008
ENSP00000368021
ENST00000378747
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 577 aa
65.9 kDa 		No 0
OPTN-009
ENSP00000368040
ENST00000378764
Q96CV9 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0001920 [negative regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016236 [macroautophagy]
GO:0017137 [Rab GTPase binding]
GO:0030674 [protein binding, bridging]
GO:0031593 [polyubiquitin binding]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0055037 [recycling endosome]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0090161 [Golgi ribbon formation]
GO:0098792 [xenophagy]
Show all
 571 aa
65.2 kDa 		No 0
OPTN-012
ENSP00000481473
ENST00000486862
A0A087WY28 [Direct mapping]
Optineurin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070530 [K63-linked polyubiquitin binding]
Show all
 107 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.