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Most malignant tissues showed weak to moderate cytoplasmic immunoreactivity with a granular pattern. Several cases of endometrial cancers and papillary adenocarcinomas of thyroid along with a few malignant melanomas, ovarian and pancreatic cancers were strongly stained. Several cases of malignant lymphomas and stomach cancers were negative.
GENE INFORMATION
Gene name
ITIH5 (HGNC Symbol)
Synonyms
MGC10848
Description
Inter-alpha-trypsin inhibitor heavy chain family, member 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
C9J2H1 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H5
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
