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Basal cell carcinomas and a few urothelial cancers showed moderate nuclear positivity. A few renal cell carcinomas and hepatocellular carcinomas displayed weak cytoplasmic immunoreactivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
HOXC13 (HGNC Symbol)
Synonyms
HOX3, HOX3G
Description
Homeobox C13 (HGNC Symbol)
Entrez gene summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001942 [hair follicle development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0035878 [nail development] GO:0043565 [sequence-specific DNA binding] GO:0043587 [tongue morphogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
