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Malignant melanomas and cervical cancers displayed moderate to strong nuclear and cytoplasmic staining. Several malignant lymphomas, breast and ovarian cancers along with a few colorectal cancers were moderately stained. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
CDK2
Synonyms
Description
Cyclin-dependent kinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000781 [chromosome, telomeric region] GO:0000793 [condensed chromosome] GO:0000805 [X chromosome] GO:0000806 [Y chromosome] GO:0002088 [lens development in camera-type eye] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006468 [protein phosphorylation] GO:0006813 [potassium ion transport] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007067 [mitotic nuclear division] GO:0007126 [meiotic nuclear division] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0015030 [Cajal body] GO:0016301 [kinase activity] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0032298 [positive regulation of DNA-dependent DNA replication initiation] GO:0032355 [response to estradiol] GO:0032403 [protein complex binding] GO:0032869 [cellular response to insulin stimulus] GO:0035173 [histone kinase activity] GO:0042493 [response to drug] GO:0043231 [intracellular membrane-bounded organelle] GO:0045471 [response to ethanol] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046686 [response to cadmium ion] GO:0046872 [metal ion binding] GO:0051298 [centrosome duplication] GO:0051301 [cell division] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051591 [response to cAMP] GO:0051602 [response to electrical stimulus] GO:0051726 [regulation of cell cycle] GO:0060968 [regulation of gene silencing] GO:0071732 [cellular response to nitric oxide]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006468 [protein phosphorylation] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007067 [mitotic nuclear division] GO:0007126 [meiotic nuclear division] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0015030 [Cajal body] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0030332 [cyclin binding] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0035173 [histone kinase activity] GO:0046872 [metal ion binding] GO:0051298 [centrosome duplication] GO:0051301 [cell division] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0060968 [regulation of gene silencing] GO:0071732 [cellular response to nitric oxide]