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SMUG1

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GENERAL INFORMATION

Gene name

 SMUG1

Gene description

 Single-strand-selective monofunctional uracil-DNA glycosylase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the centrosome & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Centrosome (uncertain)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA051149 , HPA071486
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the centrosome & vesicles.

Main location

 Vesicles (approved), Centrosome (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051149 HEK 293 Vesicles
HPA051149 MCF7 Centrosome
HPA051149 U-2 OS Centrosome
HPA071486 A549 Vesicles
HPA071486 CACO-2 Vesicles
HPA071486 U-2 OS Vesicles

GENE INFORMATION

Gene name

 SMUG1 (HGNC Symbol)

Synonyms

 FDG, HMUDG, UNG3

Description

 Single-strand-selective monofunctional uracil-DNA glycosylase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 54121277 - 54189008

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123415 (version 83.38)

Entrez gene

 23583

UniProt

 Q53HV7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53HV7

Antibodypedia

 SMUG1 antibodies

PROTEIN BROWSER
«
SMUG1-001
SMUG1-003
SMUG1-004
SMUG1-005
SMUG1-007
SMUG1-008
SMUG1-010
SMUG1-011
SMUG1-013
SMUG1-016
SMUG1-017
SMUG1-018
SMUG1-020
SMUG1-021
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMUG1-001
ENSP00000424191
ENST00000508394
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
A0A024RAZ8 [Target identity:100%; Query identity:100%]
Single-strand-selective monofunctional uracil-DNA glycosylase 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 270 aa
29.9 kDa 		No 0
SMUG1-003
ENSP00000423629
ENST00000513838
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 177 aa
19.6 kDa 		No 0
SMUG1-004
ENSP00000421139
ENST00000514685
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 177 aa
19.6 kDa 		No 0
SMUG1-005
ENSP00000338606
ENST00000337581
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
A0A024RAZ8 [Target identity:100%; Query identity:100%]
Single-strand-selective monofunctional uracil-DNA glycosylase 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 270 aa
29.9 kDa 		No 0
SMUG1-007
ENSP00000421894
ENST00000505128
D6RAI1 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
13.6 kDa 		No 0
SMUG1-008
ENSP00000243112
ENST00000243112
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 177 aa
19.6 kDa 		No 0
SMUG1-010
ENSP00000423457
ENST00000507904
D6RA25 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 108 aa
12.1 kDa 		No 0
SMUG1-011
ENSP00000427547
ENST00000506169
D6RIA4 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 90 aa
10 kDa 		No 0
SMUG1-013
ENSP00000425974
ENST00000514196
D6RI04 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 159 aa
17.6 kDa 		No 0
SMUG1-016
ENSP00000421790
ENST00000504797
D6RAS0 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 96 aa
10.6 kDa 		No 0
SMUG1-017
ENSP00000423083
ENST00000504338
D6RA78 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 172 aa
19.2 kDa 		No 0
SMUG1-018
ENSP00000425426
ENST00000503306
D6RD88 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 82 aa
9.3 kDa 		No 0
SMUG1-020
ENSP00000384828
ENST00000401977
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
A0A024RAZ8 [Target identity:100%; Query identity:100%]
Single-strand-selective monofunctional uracil-DNA glycosylase 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 270 aa
29.9 kDa 		No 0
SMUG1-021
ENSP00000421206
ENST00000506595
Q53HV7 [Direct mapping]
Single-strand selective monofunctional uracil DNA glycosylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000703 [oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity]
GO:0003677 [DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0017065 [single-strand selective uracil DNA N-glycosylase activity]
GO:0019104 [DNA N-glycosylase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045008 [depyrimidination]
Show all
 177 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.